The poster features an abstract portrayal of eight heads spiralling out from a central point, resembling a sample under a microscope. The eight heads belong to the main characters of the series, Sun Bak (a South Korean woman portrayed by Bae Doona), Nomi Marks (a white trans woman from San Francisco protrayed by Jamie Clayton), Kala Dandekar (an Indian woman portrayed by Tina Desai), Riley Blue (a white Icelandic woman portrayed by Tuppence Middleton), Wolfgang Bogdanow (a white German man portrayed by Max Riemelt), Lito Rodriguez (a Mexican man portrayed by Miguel Ángel Silvestre), Will Gorski (a white man from Chicago portrayed by Brian J. Smith), and Capheus Onyango (a black Kenyan man portrayed by Aml Ameen). The background is a mixed gradient of various greens and blues. The series title, "Sense8," is written with "Sense" in light green and "8" in black across the centre of the poster. Above the title, centered between two heads is the series tagline "I am we."

The eight central characters are arrayed in a diagonal cluster along the upper right side of the poster. Beneath them, a mirrored projection of the London cityscape slices diagonally downwards and cuts them out of the poster's bottom left corner, which features the series title, "Sense8," as well as the second season's tagline, "Survive. Together." At the top left of the cluster of people is Sun Bak, a South Korean woman with short black hair in a bright blue prison uniform, portrayed by Bae Doona, who stares achingly off to the left. Below her is Will Gorski, a white man with close-cropped brown hair and facial stubble wearing a plain grey shirt, portrayed by Brian J. Smith, who stares slightly down past camera with a frown. A little further to the right is Lito Rodriguez, a Mexican man with black hair and facial stubble wearing a dark blue shirt, portrayed by Miguel Ángel Silvestre, who also stares down past camera with a frown. Above Will and Lito, to Sun's right, Wolfgang Bogdanow embaces Kala Dandekar from behind. Wolfgang is a white German man with blonde hair and a beard wearing dark clothes, portrayed by Max Riemelt. Kala is an Indian woman with long black hair wearing a sheer black dress with bare shoulders, portrayed by Tina Desai. Both are smiling. Beneath them, to the right of Lito is Capheus Onyango, a bald black Kenyan man with a light blue shirt portrayed by Toby Onwumere, who looks off to the left mid-speech. To the right of and slightly above Capheus is Nomi Marks, a white trans woman with long brown hair wearing a peach dress, portrayed by Jamie Clayton, who stands in profile and looks off to the right. Finally, at the bottom right of the cluster is Riley Blue, a white Icelandic woman with bleached-blonde hair featuring a prominent streak of blue paint, wearing a dark red hand-knit sweater, portrayed by Tuppence Middleton, who stares off slightly to the right.

The eight central characters stand in a lineup on a rooftop with a sliver of a modern city-scape visible at the level of their knees, and a vast cloudy sky behind them rendered in the same light blue-green color as the Season 1 poster. Large blocky white text above the characters reads "Together until the end", and smaller text below the characters reads "Sense8: The Series Finale." Front and centre in the lineup is Sun Bak, a South Korean woman with black hair in a bob-cut, wearing a black-and blue checkered shirt and yoga pants, portrayed by Bae Doona. Behind Sun on the left is Lito Rodriguez, a Mexican man with short black hair wearing a dark blue dress shirt and black pants, portrayed by Miguel Ángel Silvestre. Behind Lito on the left is Capheus Onyango, a bald black Kenyan man wearing a blue-and-white sweater over a red shirt with grey pants, portrayed by Toby Onwumere, with his arms crossed in front of his chest. Behind Capheus on the left is Riley Blue, a white Icelandic woman with bleached blonde hair featuring a prominent streak of blue paint, wearing a black coat and a brown skirt with dark blue leggins, portrayed by Tuppence Middleton, with one arm reaching across her chest to grasp the elbow of her other arm. Behind Riley on the left is Will Gorski, a white man from Chicago with close-cropped dark hair, wearing a black leather jacket over a dark blue shirt with black pants, portrayed by Brian J. Smith, with his hands in his jacket pockets. Behind Sun on the right is Nomi Marks, a white trans woman from San Francisco with long brown hair, wearing a sweater with an orange, blue and grey pattern and a short dark blue skirt, portrayed by Jamie Clayton. Behind Nomi on the right is Wolfgang Bogdanow, a white German man with short blonde hair wearing a black leather jacket over a dark shirt with jeans, portrayed by Max Riemelt. Behind Wolfgang on the right is Kala Dandekar, an Indian woman with long black hair, wearing a purple-patterned shirt and a knee-lenght beige skirt, portrayed by Tina Desai.